Mbemba Ndombasi, widely known by his nickname Lofombo, began his musical journey in local groups, initially playing the drums in 1981 before switching to the bass guitar in 1983. In 1985, he joined the Orchestra of the Radio Television Nationale Congolaise (RTNC), which was then known as the Voice of Zaire (OVOZA). Due to the scarcity of bassists in Congolese music, he was frequently sought after by various groups. He went on to play with ensembles such as Super Wawa of Djo Nickel, Dynamic Acha of Liki Djo, and Super Shock, which was led by his older brother, Shora Mbemba. This phase of his career lasted until 1990, the year he further refined his bass guitar skills with the rare jazz band Sim Lipate.
A pivotal moment in Lofombo's career occurred in 1991 when he joined the renowned band Empire Bakuba, led by the late Congolese music legend, Pepe Kalle (Kabasele Ya Mpanya). He became a highly regarded member of the group and remained close to Pepe Kalle until the latter's death. Pepe Kalle's passing in 1998 deeply affected Lofombo, and subsequent tensions with some colleagues led to his eventual departure. In 1999, he established his own group, the DELTA FORCE BAND, which he continues to lead. Beyond his work with his own band, Mbemba Ndombasi, sometimes called "bendele ya Congo" (the emblem of Congo), has contributed as a bass player, arranger, producer, and programmer to numerous albums and songs for major figures in Congolese and African music, including projects for artists like Lutumba Simaro Masiya and Madilu System.